IN ORGANIC CHEMISTRY MUCH ATTENTION HAS BEEN FOCUSED ON THE SYNTHESES AND REACTIONS OF NITRONES BECAUSE OF THEIR IMPORTANCE AS SYNTHETIC TOOLS. IN FACT, MANY REPORTS HAVE APPEARED ON THE USE OF NITRONE AS REAGENTS, ESPECIALLY IN THE 1, 3-DIPOLAR CYCLOADDITION REACTIONS IN WHICH NITRONES OCCUPY A UNIQUELY IMPORTANT POSITION DUE TO THEIR SYNTHETIC SIGNIFICANCE [1]. INDEED, NITRONE CAN ACT AS A 1, 3-DIPOLE TO REACT WITH ALKENE, ALKYNE AND CYCLOPROPANE TO FORM HETEROCYCLES, WHICH ARE ALSO IMPORTANT STRUCTURAL MOTIFS FOUND IN MANY NATURAL PRODUCTS AND UNNATURAL BIOLOGICALLY ACTIVE COMPOUNDS [2, 3].WE REPORT HERE ASUITABLE METHOD FOR SYNTHESIS OF ISATIN NITRONE DERIVATIVES BY REACTION OF ISATIN CHLORIDE WITH CONVENIENT REAGENTS VIA NUCLEOPHILIC ADDITION REACTIONS IN TWO STEPS. THESTRUCTURE OF THE PRODUCTS WAS CONFIRMED BY USING IR, 1H, 13C NMR AND MASS TECHNIQUES

SCHIFF BASES FORM AN IMPORTANT CLASS OF ORGANIC COMPOUNDS WITH A WIDE VARIETY OF BIOLOGICAL PROPERTIES. DEVELOPMENT OF A NEW CHEMOTHERAPEUTIC SCHIFF BASES IS NOW ATTRACTING THE ATTENTION OF CHEMISTS AND MEDICINAL CHEMISTS. MANY STUDIES HAVE REPORTED REGARDING THE BIOLOGICAL ACTIVITIES OF SCHIFF BASES, INCLUDING THEIR ANTICANCER, ANTIBACTERIAL, ANTIFUNGAL, AND HERBICIDAL ACTIVITIES.THE USE OF IMINES AS A SCHIFF BASE IN CONSTRUCTING HETEROCYCLIC RINGS HAS BEEN STUDIED INTENSIVELY IN RECENT YEARS AND THEIR OXIDATION WAS REPORTED WITH SEVERAL OXIDIZING AGENTS SUCH AS BUFFERED OXONE, UHP/MALEIC ANHYDRIDE SYSTEM, MOLECULAR OXYGEN IN THE PRESENCE OF TRANSITION-METAL COMPLEXES AND A NITRILE/HYDROGEN PEROXIDE SYSTEM.IN CONTINUATION OF OUR PREVIOUS WORK, WE STUDY HERE THE OXIDATION REACTIONS OF SCHIFF BASES OF ISATIN DRIVATIVES BY EMPLOYING OF A CONVENIENT OXIDANT. THE NEWLY SYNTHESIZED COMPOUNDS WERE CHARACTERIZED BY IR, 1H- AND 13C-NMR AND MASS SPECTRAL DATA.

ISATIN HAS BEEN KNOWN FOR ABOUT 150 YEARS AND HAS BEEN RECENTLY FOUND, LIKE OXINDOLE ANDENDOGENOUS POLYFUNCTIONAL HETEROCYCLIC COMPOUNDS, TO EXHIBIT BIOLOGICAL ACTIVITY INMAMMALS…..

NANOSCIENCE AND NANOTECHNOLOGY IS AN AMAZING AND GROWING RESEARCH AREA THAT INCLUDES THE PREPARATION, CHARACTERIZATION AND APPLICATION OF NANOSTRUCTURES WITH VARIOUS SHAPES AND SIZES IN MANY CHEMICAL TRANSFORMATIONS. NANOPARTICLE PROPERTIES ARE SIGNIFICANTLY DIFFERENT IN THEIR BULK ANALOGUES DUE TO THEIR HIGH SURFACE-TO-VOLUME RATIO AND COORDINATION SITES WHICH PROVIDE A LARGER NUMBER OF ACTIVE SITES PER UNIT AREA [1]. IN COMPARISON WITH OTHER NANOCATALYSTS, FE3O4 NANOPARTICLES IN PARTICULAR, ARE ENVIRONMENTALLY BENIGN, ECONOMIC AND COMPARATIVELY ANTI-TOXIC [2]. FE3O4 NANOPARTICLES HAVE ATTRACTED A GREAT ATTENTION AS HETEROGENEOUS CATALYSTS BECAUSE OF THEIR INTERESTING STRUCTURE AND HIGH CATALYTIC ACTIVITIES [3] AND ALSO THEY HAVE EMERGED AS ONE OF THE MOST USEFUL HETEROGENEOUS CATALYSTS DUE TO THEIR NUMEROUS APPLICATIONS IN NANOCATALYSIS, BIOTECHNOLOGY, AND MEDICINE [4].IN THIS ARTICLE, WE REPORT THAT NANO-FE3O4 IS A HIGHLY EFFICIENT AND ECONOMICALLY VIABLE CATALYST FOR THE SYNTHESIS OF ISATIN DERIVATIVES. IN THIS STEP, IMINES ARE PRODUCED BY COMBINATION OF AMINO GROUPS AND ISATIN BY USING OF 5 MOL %FE3O4 NANOPARTICLES. AN IMPORTANT PROPERTY OF THESE NANOPARTICLES IS SIMPLE AND CONVENIENT SEPARATION FROM THE REACTION MEDIA BY A SIMPLE MAGNETIC SEPARATION.

TRIAZOLE COMPOUNDS HAVE FOUND WIDE APPLICATIONS IN PHARMACEUTICALS, AGROCHEMICALS, DYES, CORROSION INHIBITORS, BIOCHEMICALS, POLYMERS, AND FUNCTIONAL MATERIALS. BIS (INDOLYL) METHANES CONSTITUTE AN IMPORTANT CLASS OF HETEROCYCLIC COMPOUNDS THAT DISPLAY DIVERSE PHARMACOLOGICAL ACTIVITIES AND ARE USEFUL INTHE TREATMENT OF FIBROMYALGIA, CHRONIC FATIGUE AND IRRITABLE BOWEL SYNDROME...